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Week 1 NFL props, odds: Picks, predictions, bets for PrizePicks, Underdog Fantasy, Sleeper, DraftKings Pick6

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The Week 1 NFL schedule features 13 games on Sunday, which means there are plenty of NFL props in the NFL betting markets. With an over/under of 49.5 points, Texans vs. Colts is projected to be the highest-scoring game of the early window on Sunday. Second year quarterbacks C.J. Stroud and Anthony Richardson will square off for the second time in what could develop into a longtime AFC South rivalry. Both players were taken in the top five of the 2023 NFL Draft. When it comes to passing yards, Stroud has an over/under of 273.5 in the NFL player props, while Richardson’s number is 217.5. Should you target either player when making Week 1 NFL prop bets? Before making your NFL prop picks and parlay lineups on sites like PrizePicks, Underdog Fantasy, Sleeper, and DraftKings Pick 6, you need to see what SportsLine’s proven computer simulation model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2024 NFL season on an incredible 181-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 35-21 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in on the Week 1 NFL schedule and locked in its top NFL prop picks and predictions on sites like PrizePicks, Sleeper, DraftKings Pick6, and Underdog Fantasy. You can only see them by heading to SportsLine.

Top NFL prop picks for Week 1

For the Sunday NFL slate, one of the model’s top prop picks is Vikings wide receiver Justin Jefferson going over 82.5 receiving yards. Jefferson missed seven games in 2023 with a severe hamstring injury, but was still able to go over the 1,000-yard mark for the fourth-straight season. The Vikings will have a new starting quarterback in 2024 (Sam Darnold), but Jefferson was successful in 2023 when backups Nick Mullens and Jaren Hall were playing in Kirk Cousins’ absence.

Jefferson averaged a career-high 107.4 receiving yards per game in 2023, and enters the 2024 season with a career average of 98.3 yards per game. With head coach Kevin O’Connell committed to getting his top playmaker the ball, it’s easy to understand why SportsLine’s model has set such a high expectation for Jefferson in Week 1. The model is projecting 101 receiving yards for the former LSU star against the New York Giants. See the model’s other Week 1 NFL prop picks right here.

How to make picks on PrizePicks, Underdog Fantasy, Sleeper and DraftKings Pick6

The model has also identified an under-the-radar player who could go off for massive numbers because of a dream matchup. This pick could be the difference between winning your contests or going home with nothing. You can only see who it is, and get the rest of the model’s picks, here.

What are the top NFL Week 1 prop picks for PrizePicks, Underdog Fantasy, Sleeper, and DraftKings Pick6? Visit SportsLine now to see the top NFL prop picks and predictions from the SportsLine simulation model that is up well over $7,000 for $100 players on top-rated NFL picks, and find out. 





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